Pharmaceutical Autoclaves and Applications Autoclave Applications in Pharma Facilities

  • Over Pressure
  • Air Steam Mixture
  • Hot Water Spray
  • Gravity Displacement
  • Prevacuum
  • Biohazard

 

In the Pharmaceutical/Biopharmaceutical industry Tuttnauer offers a wide range of autoclaves:

 

Pure Steam Sterilization

Pre-production processing involves the sterilization of materials, equipment, containers and other items entering the production floor.

Post-production sterilizers are used for terminal sterilization of finished goods.

Laboratory applications have a broad scope mainly R&D (product development, manufacturing process development, packaging selection) and Quality Control (QC).

Pre & Post Vacuum

Pre-vacuum removes air trapped in loads such as garments and hollow loads to achieve effective steam penetration. Post-vacuum assists in quick drying to reduce sterilization cycle times. Ideal for hard and porous loads.

Gravity Displacement

Sterilization is achieved when steam enters the chamber and displaces the air, ideal for liquid loads.




Common Applications  Common Program Cycles Common Optional Features
Solid Loads Machine Parts
Empty glassware
Stainless steel parts / vessels

 

Pre & Post Vacuum
Unwrapped solid
Wrapped Porous

 

 

Gravity
Liquid (open)
Liquid (sealed)

 

Test Cycles
Leak
Bowie & Dick
Filter sterilization

Air Detector (hard and porous)
Steam Quality Check
Sanitary Filter
Automatic Water Intrusion Test
Multipurpose Valve
Bio-shield
Jacket cooling (liquid loads)
Steam Generator
Porous Loads Textile
Filters (ATF process) Rubber stoppers Cleaning aids
Tubing
Liquid Non-Sealed Beakers
Bottles
 

 

Over Pressure Sterilization

Over pressure sterilization is a precisely controlled process ideal for terminal sterilization of soft packaged items especially sealed liquids, parenteral and ophthalmic products.

Air Steam Mixture (ASM) - Sterilization is achieved by circulating a mixture of Air & Steam in the chamber ideal for small sized delicate product packaging.

Hot Water Spray (HWS) -  Sterilization is achieved by circulating hot water over the load.



Common Applications Common Program Cycles Common Optional Features
Sealed Liquid
Sealed Ampoule/Vials
Sealed IV Bags/bottles
Pre-Filled Syringe (PFS)
Sealed Contact Lenses

Liquids (sealed)
Ampoule  Leak Detection
ASM Cycles
Air Steam Mixture
Filter Sterilization
HWS Cycles
Hot Water Spray
Cleaning-In-Place  (CIP)

Bio-shield
ASM Features
Steam quality check
Jacket cooling system
HWS Features
In-chamber sprinkling system
Water circulation pump

 

 

Biohazard Waste Sterilization

Tuttnauer’s bio-hazard sterilizers decontaminate dangerous pathogens prior to disposal. Tuttnauer provides autoclaves suitable for biosafety (BSL) applications. The autoclaves are based on pure steam sterilization.


Common Applications Common Program Cycles Common Optional Features
Biohazard
Biological Waste Disposal
Biohazard liquid
Biohazard solid
Thermal Biohazard
Biohazard Filter
Blow-off Tank
Bio-shield

 

Pharma Autoclaves in Pharmaceutical Production Facility

 

Pre-Production Production & Filling Area Post-Production
A1. Pure Steam Sterilizer (Hard Loads) 2. Reactor 1 1. Control Station
A2. Pure Steam Sterilizer (Liquid Loads) 3. Reactor 2  
5. Pass-through Window 4. Filling Machine  
  T1. Pure Steam Sterilizer (Bulk Capacity)  
  T2. Over-Pressure Sterilizer (Bulk Capacity)  
  B. Biohazard Sterilizer